SIN001 is the world’s first Class 1.1 anti-cancer drug targeting the BAD (Ser99) phosphorylation site. It directly blocks BAD phosphorylation, restores apoptosis, and overcomes drug resistance associated with multiple kinase inhibitors. It shows potent activity against breast, lung, ovarian, colorectal, and endometrial cancers. Supported by a world-leading interdisciplinary team, SIN001 features high specificity, low side effects, and strong synergy with other therapies. It is expected to become a first-in-class core drug for solid tumors and address unmet clinical needs in drug-resistant cancers.